AZ 11645373 is a selective antagonist of the human P2X7 receptor, demonstrating significant potency without affecting the rat variant. It effectively inhibits ATP-induced release of IL-1β from lipopolysaccharide-activated THP-1 cells, with an IC50 value of 90 nM. This compound is valuable for studies focused on inflammatory processes and purinergic signaling pathways.
AZ 11645373 is a selective antagonist of the human P2X7 receptor, demonstrating significant potency without affecting the rat variant. It effectively inhibits ATP-induced release of IL-1β from lipopolysaccharide-activated THP-1 cells, with an IC50 value of 90 nM. This compound is valuable for studies focused on inflammatory processes and purinergic signaling pathways.
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