AZ'3137 is an orally bioavailable PROTAC-based degrader specifically targeting the androgen receptor (AR). It exhibits a DC50 value of 22 nM for AR degradation and efficiently degrades the L702H mutant variant with a DC50 of 92 nM. AZ'3137 demonstrates significant inhibition of LNCaP cell proliferation with a GI50 of 74 nM and effectively suppresses AR signaling and tumor growth in prostate cancer mouse models. This compound is suitable for studies investigating AR-targeted therapies in prostate cancer.
AZ'3137 is an orally bioavailable PROTAC-based degrader specifically targeting the androgen receptor (AR). It exhibits a DC50 value of 22 nM for AR degradation and efficiently degrades the L702H mutant variant with a DC50 of 92 nM. AZ'3137 demonstrates significant inhibition of LNCaP cell proliferation with a GI50 of 74 nM and effectively suppresses AR signaling and tumor growth in prostate cancer mouse models. This compound is suitable for studies investigating AR-targeted therapies in prostate cancer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
