AZ 3146

Catalog No.: A11170

Mps1 inhibitor

AZ 3146

AZ 3146 Chemical Structure

CAS NO. 1124329-14-1

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $80.00

Special Price $64.00

50 mg

Regular Price: $240.00

Special Price $192.00

100 mg

Regular Price: $450.00

Special Price $360.00

10mM * 1mL in DMSO
$90.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Targets
Mps1
~35 nM
In vitro DMSO 28 mg/mL (61.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 91 mg/mL (201.08 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.49 mL 220.97 mL
0.5 mM 4.42 mL 22.1 mL 44.19 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11170
Actions Inhibitor
M. Wt 452.55
Formula C24H32N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1124329-14-1
Synonyms AZ-3146
SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC

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