AZD1152

Catalog No.: A15011

Aurora B inhibitor

AZD1152

AZD1152 Chemical Structure

CAS NO. 722543-31-9

AZD1152 is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML).

Availability: In stock

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20 mg

Regular Price: $300.00

Special Price $240.00

50 mg

Regular Price: $470.00

Special Price $376.00

100 mg

Regular Price: $920.00

Special Price $736.00

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Biological Activity

AZD1152 is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.02 mL 85.1 mL 170.2 mL
0.5 mM 3.4 mL 17.02 mL 34.04 mL
1 mM 1.7 mL 8.51 mL 17.02 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 587.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15011
Actions Inhibitor
CAS No. 722543-31-9
Formula C26H31FN7O6P
M. Wt 587.54
Purity >98%
Synonyms Barasertib, AZD-1152, AZD 1152
SMILES CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCOP(=O)(O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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