Azetukalner is a selective Kv7.2/Kv7.3 potassium channel activator, demonstrating an EC50 of 27 nM. This compound exhibits approximately four-fold selectivity for the Kv7.2/7.3 combination over Kv7.3/7.5 and Kv7.4 channels, with EC50 values of 94 nM and 113 nM, respectively. Azetukalner's specificity exceeds 100-fold for Kv7 channels when compared to other ion channels and receptors. This reagent is valuable for research focused on focal epilepsy.
Azetukalner is a selective Kv7.2/Kv7.3 potassium channel activator, demonstrating an EC50 of 27 nM. This compound exhibits approximately four-fold selectivity for the Kv7.2/7.3 combination over Kv7.3/7.5 and Kv7.4 channels, with EC50 values of 94 nM and 113 nM, respectively. Azetukalner's specificity exceeds 100-fold for Kv7 channels when compared to other ion channels and receptors. This reagent is valuable for research focused on focal epilepsy.
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