Azide-PEG12-alcohol serves as a PEG-based linker for the development of PROTACs, facilitating targeted protein degradation through a well-defined chemistry. This compound contains an azide functionality, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Azide-PEG12-alcohol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified substrates, making it an invaluable tool for advancing chemical biology and therapeutic research.
Azide-PEG12-alcohol serves as a PEG-based linker for the development of PROTACs, facilitating targeted protein degradation through a well-defined chemistry. This compound contains an azide functionality, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Azide-PEG12-alcohol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified substrates, making it an invaluable tool for advancing chemical biology and therapeutic research.
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