Azido-PEG1-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO- or BCN-modified compounds. Azido-PEG1-azide is invaluable for researchers developing novel targeted protein degradation strategies.
Azido-PEG1-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO- or BCN-modified compounds. Azido-PEG1-azide is invaluable for researchers developing novel targeted protein degradation strategies.
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