Azido-PEG1-CH2COO-Cl is a versatile PROTAC linker that facilitates targeted protein degradation by connecting E3 ligases with specific target proteins. This linker is critical for the synthesis of compounds such as PROTAC BRD4 Degrader-1. Featuring an azide functional group, Azido-PEG1-CH2COO-Cl participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne and DBCO or BCN-modified molecules, respectively. Its unique reactivity makes it an essential tool in chemical biology and therapeutic development.
Azido-PEG1-CH2COO-Cl is a versatile PROTAC linker that facilitates targeted protein degradation by connecting E3 ligases with specific target proteins. This linker is critical for the synthesis of compounds such as PROTAC BRD4 Degrader-1. Featuring an azide functional group, Azido-PEG1-CH2COO-Cl participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne and DBCO or BCN-modified molecules, respectively. Its unique reactivity makes it an essential tool in chemical biology and therapeutic development.
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