Fig. 1 · Structure
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Azido-PEG1-NHS ester
PROTAC Linker
Azido-PEG1-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide functional group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG1-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups. Its robust chemical reactivity makes it a valuable tool in targeted protein degradation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1807530-06-8 |
| Applications | PROTAC Linker |
| Formula | C9H12N4O5 |
| Molecular Weight | 256.22 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCN=[N+]=[N-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.