Azido-PEG1-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide functional group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG1-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups. Its robust chemical reactivity makes it a valuable tool in targeted protein degradation studies.
Azido-PEG1-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide functional group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG1-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN groups. Its robust chemical reactivity makes it a valuable tool in targeted protein degradation studies.
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