Azido-PEG12-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through click chemistry. It features an azide group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds incorporating DBCO or BCN groups. This versatility makes Azido-PEG12-alcohol a valuable tool for advancing targeted protein degradation research and related applications in chemical biology.
Azido-PEG12-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through click chemistry. It features an azide group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds incorporating DBCO or BCN groups. This versatility makes Azido-PEG12-alcohol a valuable tool for advancing targeted protein degradation research and related applications in chemical biology.
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