Azido-PEG12-propargyl is a versatile PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as enabling ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Its effective application in the development of PROTACs supports targeted protein degradation research, offering significant potential for therapeutic interventions in various diseases.
Azido-PEG12-propargyl is a versatile PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as enabling ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Its effective application in the development of PROTACs supports targeted protein degradation research, offering significant potential for therapeutic interventions in various diseases.
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