Azido-PEG3-aminoacetic acid-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs, specifically targeting the engagement of E3 ligases for protein degradation. This compound features an azide group, facilitating click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology applications and the development of targeted protein degradation strategies.
Azido-PEG3-aminoacetic acid-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs, specifically targeting the engagement of E3 ligases for protein degradation. This compound features an azide group, facilitating click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology applications and the development of targeted protein degradation strategies.
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