Azido-PEG3-O-NHS ester serves as a versatile PEG-based linker for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide functional group, facilitating efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, interacting with DBCO or BCN functionalized substrates, making it essential for applications in chemical biology and targeted protein degradation research.
Azido-PEG3-O-NHS ester serves as a versatile PEG-based linker for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide functional group, facilitating efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, interacting with DBCO or BCN functionalized substrates, making it essential for applications in chemical biology and targeted protein degradation research.
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