Azido-PEG3-S-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the degradation of specific proteins. This versatile reagent features an azide and an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Its applications include facilitating targeted protein degradation and the development of novel therapeutic strategies in chemical biology and drug discovery.
Azido-PEG3-S-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the degradation of specific proteins. This versatile reagent features an azide and an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Its applications include facilitating targeted protein degradation and the development of novel therapeutic strategies in chemical biology and drug discovery.
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