Azido-PEG3-SS-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the ubiquitin-proteasome system. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, facilitating the development of versatile PROTAC constructs for targeted protein degradation studies.
Azido-PEG3-SS-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the ubiquitin-proteasome system. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, facilitating the development of versatile PROTAC constructs for targeted protein degradation studies.
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