Azido-PEG3-Sulfone-PEG4-Boc is a PEG-derived linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing partners. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatility makes Azido-PEG3-Sulfone-PEG4-Boc a valuable tool for studies in targeted protein degradation and other applications in chemical biology.
Azido-PEG3-Sulfone-PEG4-Boc is a PEG-derived linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing partners. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatility makes Azido-PEG3-Sulfone-PEG4-Boc a valuable tool for studies in targeted protein degradation and other applications in chemical biology.
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