Azido-PEG4-THP is a PEG-based linker designed for use in the synthesis of PROTACs. It features an azide group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes Azido-PEG4-THP an essential tool in chemical biology for the development of targeted protein degradation strategies.
Azido-PEG4-THP is a PEG-based linker designed for use in the synthesis of PROTACs. It features an azide group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes Azido-PEG4-THP an essential tool in chemical biology for the development of targeted protein degradation strategies.
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