Azido-PEG5-S-methyl ethanethioate functions as a versatile linker in the synthesis of PROTACs, utilizing its PEG-based structure to enhance solubility and stability. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne moieties and entities containing DBCO or BCN groups, respectively. Its utility in PROTAC development makes it an essential tool for researchers investigating targeted protein degradation mechanisms.
Azido-PEG5-S-methyl ethanethioate functions as a versatile linker in the synthesis of PROTACs, utilizing its PEG-based structure to enhance solubility and stability. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne moieties and entities containing DBCO or BCN groups, respectively. Its utility in PROTAC development makes it an essential tool for researchers investigating targeted protein degradation mechanisms.
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