Azido-PEG8-propargyl is a PEG-linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group and an alkyne moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. It also demonstrates reactivity through strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Azido-PEG8-propargyl is an effective tool for creating targeted protein degradation systems in chemical biology research.
Azido-PEG8-propargyl is a PEG-linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group and an alkyne moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. It also demonstrates reactivity through strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Azido-PEG8-propargyl is an effective tool for creating targeted protein degradation systems in chemical biology research.
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