Azido-PEG9-amine is a non-cleavable linker comprising a 9-unit polyethylene glycol (PEG) chain, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This versatile reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it suitable for applications in PROTAC synthesis and click chemistry.
Azido-PEG9-amine is a non-cleavable linker comprising a 9-unit polyethylene glycol (PEG) chain, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This versatile reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it suitable for applications in PROTAC synthesis and click chemistry.
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