Azido-PEG9-S-methyl ethanethioate is a PEG-based linker designed for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in targeted protein degradation research.
Azido-PEG9-S-methyl ethanethioate is a PEG-based linker designed for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in targeted protein degradation research.
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