β-Funaltrexamine hydrochloride is a selective and irreversible antagonist of the μ opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by reducing TLR4 signaling, inhibiting cytokine-induced iNOS activation and neuroinflammation, and mitigating neuronal degeneration. Additionally, β-funaltrexamine hydrochloride inhibits NF-κB signaling and chemokine expression in human astrocytes and murine models. It is a valuable tool for research related to neurodegenerative diseases, including stroke.
β-Funaltrexamine hydrochloride is a selective and irreversible antagonist of the μ opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by reducing TLR4 signaling, inhibiting cytokine-induced iNOS activation and neuroinflammation, and mitigating neuronal degeneration. Additionally, β-funaltrexamine hydrochloride inhibits NF-κB signaling and chemokine expression in human astrocytes and murine models. It is a valuable tool for research related to neurodegenerative diseases, including stroke.
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