B-Raf IN 11 is a selective inhibitor of the B-RafV600E mutant kinase, demonstrating an IC50 of 76 nM, and exhibits an IC50 of 238 nM against wild-type B-Raf kinase. This compound effectively inhibits the kinase activities of both B-RafV600E mutant and wild-type B-Raf, making it a valuable tool for investigating pathways related to colorectal cancer. Its application in research provides insight into therapeutic strategies targeting B-Raf mutations in cancer treatment.
B-Raf IN 11 is a selective inhibitor of the B-RafV600E mutant kinase, demonstrating an IC50 of 76 nM, and exhibits an IC50 of 238 nM against wild-type B-Raf kinase. This compound effectively inhibits the kinase activities of both B-RafV600E mutant and wild-type B-Raf, making it a valuable tool for investigating pathways related to colorectal cancer. Its application in research provides insight into therapeutic strategies targeting B-Raf mutations in cancer treatment.
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