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Bardoxolone (CDDO)

Catalog No.: A11324

IκB/IKK inhibitor

Bardoxolone (CDDO)

Bardoxolone (CDDO) Chemical Structure

CAS NO. 218600-44-3

Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).

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  • Rothan HA, .et al. Small molecule grp94 inhibitors block dengue and Zika virus replication, Antiviral Res, 2019, Aug 14;171:104590 PMID: 31421166
  • Turpaev K, .et al. Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines, Eur J Pharmacol, 2016, Aug 5;784:69-80 PMID: 27178899

Biological Activity

Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
In vitro DMSO 5 mg/mL (10.17 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.34 mL 101.7 mL 203.39 mL
0.5 mM 4.07 mL 20.34 mL 40.68 mL
1 mM 2.03 mL 10.17 mL 20.34 mL
5 mM 0.41 mL 2.03 mL 4.07 mL

*The above data is based on the productmolecular weight 491.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11324
Actions Inhibitor
CAS No. 218600-44-3
Formula C31H41NO4
M. Wt 491.66
Purity >98%
Synonyms RTA 401, Bardoxolone
SMILES C[[email protected]@]12CC[[email protected]]3(CCC(C[[email protected]]3[[email protected]]1C(=O)C=C4[[email protected]]2(CC[[email protected]@H]5[[email protected]@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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