Batimastat (BB-94)

Catalog No.: A12985

MMP inhibitor

Batimastat (BB-94)

Batimastat (BB-94) Chemical Structure

CAS NO. 130370-60-4

Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$140.00
25 mg
$240.00
50 mg
$380.00
10mM * 1mL in DMSO
$145.00
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Biological Activity

Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively.
Targets
MMP-1 MMP-2 MMP-9 MMP-7 MMP-3
3 nM4 nM4 nM6 nM20 nM
In vitro (25°C) DMSO 84 mg/mL (175.86 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.94 mL 104.68 mL 209.36 mL
0.5 mM 4.19 mL 20.94 mL 41.87 mL
1 mM 2.09 mL 10.47 mL 20.94 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12985
Actions Inhibitor
CAS No. 130370-60-4
Formula C23H31N3O4S2
M. Wt 477.64
Purity >98%
Synonyms BB 94
SMILES CC(C)C[[email protected]]([[email protected]](CSC1=CC=CS1)C(=O)NO)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)NC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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