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  1. Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.
  2. Matrix Metalloproteinase Inhibitor

    CTS-1027 is a potent MMP inhibitor that protects Against TNFα- and α-Fas-Induced liver Injury.
  3. MMP inhibitor

    Marimastat acted as a broad-spectrum matrix metalloproteinase inhibitor.
  4. MMP inhibitor

    4-epi-Chlortetracycline Hydrochloride is a tetracycline derivative that acts as a metalloproteinase (MMP) inhibitor, used in treating tissue destructive diseases and cancer
  5. matrix metalloproteinase-13 (MMP-13) inhibitor

    T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.
  6. MMP inhibitor

    Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively.
  7. MT1-MMP inhibitor

    NSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L).
  8. MMP-3 inhibitor

    MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM.
  9. MMP inhibitor

    GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs).
  10. dual TACE/MMPs inhibitor

    Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) .
  11. MMP-13 inhibitor

    CL-82198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 mg/ml.
  12. TACE/MMP inhibitor

    TAPI-0 is an inhibitor of TACE (IC50 = 50-100 nM) as well as other matrix and membrane metalloproteases
  13. TACE/MMP inhibitor

    TAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). TAPI-2 blocks release of DCC7, APP, TNFα, L-selectin, NOTCH, TGFα, IL-6R9, erbB2/HER2, and ACE. This inhibitor has been used in tissue culture.
  14. TACE/MMP inhibitor

    TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
  15. MMP-2/MMP-9 inhibitor

    SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9.
  16. MMP-2 inhibitor

    ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.
  17. MMP-2 inhibitor

    ARP 101, selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).
  18. MMP inhibitor

    CP 471474, broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively).
  19. Broad spectrum MMP inhibitor

    ONO 4817 is used for testing effective treatment of MMP-related diseases.
  20. Broad spectrum MMP inhibitor

    PD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14.
  21. MMP inhibitor

    Ro 32-3555 is a potent, collagenase-selective MMP inhibitor .
  22. MMP-3/MMP-12 Inhiibitor

    UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor .
  23. MMP-13 inhibitor

    WAY 170523 has been reported to be a selective and potent inhibitor of MMP-13.
  24. MMP-3 inhibitor

    UK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs.
  25. MMP Inhibitor

    Batimastat is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor.
  26. MMP Inhibitor

    20(R)-Ginsenoside Rh2 is a matrix metalloproteinase (MMP) inhibitor that acts as a cell antiproliferator.
  27. metalloproteinase inhibitor

    Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice.
  28. Atox1/CCS inhibitor

    DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport.
  29. MMP9 inhibitor

    JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM.
  30. TACE/MMP inhibitor

    TMI-1 is a novel orally active dual inhibitor of ADAM17 (TACE) and MMP.
  31. MMP inhibitor

    Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
  32. MMP inhibitor

    Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.
  33. MMP inhibitor

    Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.
  34. MMP-13 inhibitor

    DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity.
  35. MMP inhibitor

    BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
  36. metalloproteinase inhibitor

    Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively.
  37. CP4H1 inhibitor

    PythiDC is a selective inhibitor of collagen prolyl 4-hydroxylase.

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