BayCysLT2 is a selective and potent antagonist of the cysteinyl leukotriene 2 (CysLT2) receptor, exhibiting an IC50 value of 53 nM. It effectively inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. Additionally, BayCysLT2 demonstrates the ability to reverse LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated guinea pig hearts, making it valuable for research on cardiovascular and inflammatory responses.
BayCysLT2 is a selective and potent antagonist of the cysteinyl leukotriene 2 (CysLT2) receptor, exhibiting an IC50 value of 53 nM. It effectively inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. Additionally, BayCysLT2 demonstrates the ability to reverse LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated guinea pig hearts, making it valuable for research on cardiovascular and inflammatory responses.
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