BBT is a calcium channel modulator that enhances glucose-stimulated insulin secretion (GSIS) while exhibiting anti-hyperglycemic activity. In models of type 2 diabetes, BBT protects pancreatic β-cells from cytokine- or streptozotocin-induced cell death. Its mechanism of action involves the cAMP/PKA signaling pathway and the long-lasting activation of L-type voltage-dependent calcium channels and CaMK2 pathways, making it a valuable tool for diabetic research and therapeutic studies.
BBT is a calcium channel modulator that enhances glucose-stimulated insulin secretion (GSIS) while exhibiting anti-hyperglycemic activity. In models of type 2 diabetes, BBT protects pancreatic β-cells from cytokine- or streptozotocin-induced cell death. Its mechanism of action involves the cAMP/PKA signaling pathway and the long-lasting activation of L-type voltage-dependent calcium channels and CaMK2 pathways, making it a valuable tool for diabetic research and therapeutic studies.
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