Calcium Channels

Cat. No.

A14023

CAS No.

126150-97-8

BAPTA/AM

Synonyms: BAPTA-AM

BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

Cat. No.

A10487

CAS No.

75695-93-1

Isradipine

Synonyms: DynaCirc; Prescal; PN-200-110; Clivoten; Esradin

Isradipine is a calcium channel blocker of the dihydropyridine class.

Cat. No.

A10554

CAS No.

89226-75-5

Manidipine 2HCl

Synonyms: CV-4093

Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.

Cat. No.

A10645

CAS No.

66085-59-4

Nimodipine

Nimodipine is a L-type Ca2+ channel blocker.

Cat. No.

A10068

CAS No.

88150-42-9

Amlodipine

Synonyms: Istin; Norvasc; Caduet

Amlodipin is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease.

Cat. No.

A10069

CAS No.

111470-99-6

Amlodipine besylate

Synonyms: Istin; Norvasc

Amlodipine-besylate is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease.

Cat. No.

A10215

CAS No.

132203-70-4

Cilnidipine

Synonyms: FRC 8653

Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply.

Cat. No.

A10309

CAS No.

56-53-1

Diethylstilbestrol

Synonyms: Diethylstilboestrol; DES; BAN stilboestrol

Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor.

Cat. No.

A10311

CAS No.

33286-22-5

Diltiazem HCl

Diltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.

Cat. No.

A10383

CAS No.

72509-76-3

Felodipine

Synonyms: Plendil; H 154/82

Felodipine is a 1,4-dihydropyridine antagonist and calcium channel protein inhibitor.

Cat. No.

A10553

CAS No.

89226-50-6

Manidipine (Manyper)

Synonyms: Artedil; Iperten; Manyper

Manidipine is a dihydropyridine compound and calcium channel protein inhibitor and antagonist.

Cat. No.

A10643

CAS No.

21829-25-4

Nifedipine

Nifedipine is a L-type calcium channel blocker.

Cat. No.

A10646

CAS No.

63675-72-9

Nisoldipine

Synonyms: BAY-k 5552

Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

Cat. No.

A10648

CAS No.

39562-70-4

Nitrendipine

Synonyms: BAY-E-5009

Nitrendipine is a dihydropyridine calcium channel blocker primarily acting on L-type calcium channels. It exhibits significant antihypertensive properties and has been shown to induce apoptosis in various cellular contexts, including neuroblastoma. Additionally, Nitrendipine alleviates withdrawal symptoms associated with alcohol and morphine and reduces right ventricular hypertrophy and pulmonary vascular alterations induced by intermittent hypoxia. Its diverse biological activities make it valuable in research related to cardiovascular health and cancer biology.

Cat. No.

A10921

CAS No.

518-34-3

Tetrandrine (Fanchinine)

Synonyms: Fanchinine; Hanfangchin A; NSC 77037; S,S-(+)-Tetrandrine; Sinomenine A; TTD; Tetrandrin; d-Tetrandr

Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis.

Cat. No.

A11219

CAS No.

123524-52-7

Azelnidipine

Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. that attenuates liver fibrosis and may increase antioxidant defence.

Cat. No.

A11405

CAS No.

83207-58-3

Astragaloside A

Synonyms: Astragaloside IV; Astramembrannin I; Cyclosiversioside F

Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia.

Cat. No.

A11729

CAS No.

103890-78-4

Lacidipine

Synonyms: Lacipil; Motens

Lacidipine is a calcium channel blocker

Cat. No.

A11730

CAS No.

91599-74-5

Benidipine hydrochloride

Benidipine hydrochloride is a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus.

Cat. No.

A11731

CAS No.

75530-68-6

Nilvadipine (ARC029)

Synonyms: ARC029

Nilvadipine is a calcium channel blocker (CCB) used for the treatment of hypertension and chronic major cerebral artery occlusion

Cat. No.

A11746

CAS No.

167221-71-8

Clevidipine

Synonyms: Cleviprex

Clevidipine is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable.

Cat. No.

A11839

CAS No.

2468-21-5

Catharanthine

Synonyms: (+)-3,4-Didehydrocoronaridine

Catharanthine, a potent inhibitor of voltage-operated L-type Ca2+ channels (VOCC), demonstrates significant activity in the modulation of calcium ion influx. With IC50 values of 220 μM and 8 μM in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively, it effectively lowers blood pressure and heart rate. Furthermore, Catharanthine exhibits anti-cancer properties, making it valuable for various research applications in cardiovascular and cancer studies.

Cat. No.

A11858

CAS No.

30484-77-6

Flunarizine dihydrochloride

Flunarizine dihydrochloride is a potent dual blocker of Na+ and Ca2+ channels, specifically targeting T-type calcium channels. This compound exhibits significant anticonvulsant and antimigraine properties, making it valuable for neurological research. Additionally, Flunarizine dihydrochloride demonstrates peripheral vasodilatory effects, enhancing its potential applications in vascular studies.

Cat. No.

A12171

CAS No.

953778-58-0

MK-8998

MK-8998 (compound 33) is a potent and selective inhibitor of the T-type calcium channel.

Cat. No.

A12186

CAS No.

1402821-24-2

Ca2+ channel agonist 1

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.