BC11-38 is a selective inhibitor of phosphodiesterase 11 (PDE11) with an IC50 of 0.28 µM, demonstrating over 100-fold selectivity against other PDE isoforms (PDE1-10). This compound effectively elevates cyclic AMP (cAMP) levels, enhancing protein kinase A (PKA)-mediated phosphorylation of ATF-1 and stimulating cortisol production in H295R cells. BC11-38 is valuable for research into the regulatory mechanisms of cAMP signaling and its implications in endocrine function.
BC11-38 is a selective inhibitor of phosphodiesterase 11 (PDE11) with an IC50 of 0.28 µM, demonstrating over 100-fold selectivity against other PDE isoforms (PDE1-10). This compound effectively elevates cyclic AMP (cAMP) levels, enhancing protein kinase A (PKA)-mediated phosphorylation of ATF-1 and stimulating cortisol production in H295R cells. BC11-38 is valuable for research into the regulatory mechanisms of cAMP signaling and its implications in endocrine function.
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