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BC21

Catalog No.: A37136
β-catenin/Tcf4 Inhibitor
BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. It disrupts the interaction between β-catenin and Tcf4-derived peptides, thereby inhibiting β-catenin/Tcf4-mediated transcriptional activity. This compound is particularly valuable in cancer research, where aberrant β-catenin signaling plays a critical role in tumor progression.
BC21 691005-38-6 β-catenin/Tcf4 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. It disrupts the interaction between β-catenin and Tcf4-derived peptides, thereby inhibiting β-catenin/Tcf4-mediated transcriptional activity. This compound is particularly valuable in cancer research, where aberrant β-catenin signaling plays a critical role in tumor progression.
Product Information
Catalog NumA37136
FormulaC32H36Cl2Cu2N2O2
Molecular Weight678.64
CAS Number691005-38-6
SMILESC12=CC=C3C(C=CC=C3)=C1C[N]4(CCCCC4)[Cu+2]5([O-]2)[Cl-][Cu+2]6([N]7(CCCCC7)CC8=C(C=CC=C9)C9=CC=C8[O-]6)[Cl-]5
SynonymsNSC 109268
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Stem Cells/Wnt > β-catenin