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Biological Activity
Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.
Targets
| DNA synthesis (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | 69 mg/mL (174.8 mM) | |
| Water | 2 mg/mL (5.06 mM) | ||
| Ethanol | 15 mg/mL (37.99 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.34 mL | 126.68 mL | 253.36 mL |
| 0.5 mM | 5.07 mL | 25.34 mL | 50.67 mL |
| 1 mM | 2.53 mL | 12.67 mL | 25.34 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10124 |
|---|---|
| CAS No. | 3543-75-7 |
| Formula | C16H21Cl2N3O2.HCl |
| M. Wt | 394.7 |
| Purity | >98% |
| Synonyms | Ribomustin, Treanda, SDX-105, Treakisym |
| SMILES | CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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