Bendamustine HCl (SDX-105)

Catalog No.: A10124

Bendamustine HCl (SDX-105) Chemical Structure

CAS NO. 3543-75-7

Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.

Availability: In stock

Package Price Qty
25 mg
$40.00
50 mg
$70.00
100 mg
$120.00
10mM * 1mL in DMSO
$65.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.

Targets
DNA synthesis (Cell-free assay)
In vitro (25°C) DMSO 79 mg/mL (200.14 mM)
Water 15 mg/mL (38 mM)
Ethanol 17 mg/mL (43.06 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.34 mL 126.68 mL 253.36 mL
0.5 mM 5.07 mL 25.34 mL 50.67 mL
1 mM 2.53 mL 12.67 mL 25.34 mL
5 mM 0.51 mL 2.53 mL 5.07 mL

*The above data is based on the productmolecular weight 394.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10124
Actions No
M. Wt 394.7
Formula C16H21Cl2N3O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 3543-75-7
Synonyms Ribomustin, Treanda, SDX-105, Treakisym
SMILES CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl

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