Bendamustine HCl (SDX-105)

Catalog No.: A10124

Bendamustine HCl (SDX-105)

Bendamustine HCl (SDX-105) Chemical Structure

CAS NO. 3543-75-7

Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.

Availability: In stock

Package Price Qty
25 mg
$40.00
50 mg
$70.00
100 mg
$120.00
10mM * 1mL in DMSO
$65.00
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Biological Activity

Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe.

Targets
DNA synthesis (Cell-free assay)
In vitro (25°C) DMSO 69 mg/mL (174.8 mM)
Water 2 mg/mL (5.06 mM)
Ethanol 15 mg/mL (37.99 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.34 mL 126.68 mL 253.36 mL
0.5 mM 5.07 mL 25.34 mL 50.67 mL
1 mM 2.53 mL 12.67 mL 25.34 mL
5 mM 0.51 mL 2.53 mL 5.07 mL

*The above data is based on the productmolecular weight 394.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10124
CAS No. 3543-75-7
Formula C16H21Cl2N3O2.HCl
M. Wt 394.7
Solubility DMSO
Purity >98%
Synonyms Ribomustin, Treanda, SDX-105, Treakisym
SMILES CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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