Benzquinamide hydrochloride targets the α2 adrenergic receptors (α2-AR), binding with Ki values of 1,365, 691, and 545 nM for the α2A, α2B, and α2C subtypes, respectively. As an antiemetic, it exhibits significant efficacy in preventing nausea and vomiting. Additionally, benzquinamide inhibits P-glycoprotein-mediated drug efflux, thereby enhancing the cytotoxic effects of anticancer agents in multidrug-resistant cell lines, making it a valuable tool in cancer research and therapeutic development.
Benzquinamide hydrochloride targets the α2 adrenergic receptors (α2-AR), binding with Ki values of 1,365, 691, and 545 nM for the α2A, α2B, and α2C subtypes, respectively. As an antiemetic, it exhibits significant efficacy in preventing nausea and vomiting. Additionally, benzquinamide inhibits P-glycoprotein-mediated drug efflux, thereby enhancing the cytotoxic effects of anticancer agents in multidrug-resistant cell lines, making it a valuable tool in cancer research and therapeutic development.
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