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Biological Activity
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.28 mL | 86.4 mL | 172.8 mL |
| 0.5 mM | 3.46 mL | 17.28 mL | 34.56 mL |
| 1 mM | 1.73 mL | 8.64 mL | 17.28 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.46 mL |
*The above data is based on the productmolecular weight 578.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21346 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 797035-11-1 |
| Formula | C31H38N4O5S |
| M. Wt | 578.72 |
| Purity | >98% |
| SMILES | O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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