Beta-secretase (BACE)

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  1. BACE1 inhibitor

    LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments.
  2. BACE1 inhibitor

    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
  3. BACE1 inhibitor

    BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
  4. BACE1 inhibitor

    Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM.
  5. BACE1 inhibitor

    AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM.
  6. nonsteroidal glucocorticoid receptor agonist

    AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist.
  7. BACE1 inhibitor

    AMG-8718 is a potent and orally efficacious BACE1 inhibitor.
  8. BACE1 Inhibitor

    Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage.
  9. β-secretase/BACE1 inhibitor

    Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
  10. BACE1 inhibitor

    BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer's disease.
  11. BACE-1 inhibitor

    Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.
  12. Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
  13. BACE1 inhibitor

    BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM.
  14. BACE-1 inhibitor

    Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor for the treatment of Alzheimer's disease (AD).
  15. BACE-1 inhibitor

    BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC50 of 56 nM.
  16. BACE1 inhibitor

    PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
  17. BACE1 inhibitor

    LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.
  18. BACE-1 inhibitor

    β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
  19. BACE1 inhibitor

    AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
  20. BACE1 inhibitor

    Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction.

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