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Biological Activity
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.03 mL | 100.13 mL | 200.26 mL |
| 0.5 mM | 4.01 mL | 20.03 mL | 40.05 mL |
| 1 mM | 2 mL | 10.01 mL | 20.03 mL |
| 5 mM | 0.4 mL | 2 mL | 4.01 mL |
*The above data is based on the productmolecular weight 499.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19064 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2244452-09-1 |
| Formula | C21H20Cl2N2O6S |
| M. Wt | 499.36 |
| Purity | >98% |
| Synonyms | BI 4924; BI4924 |
| SMILES | O=C(O)CS(=O)(C1=CC=C([C@H](NC(C(N2C)=CC3=C2C=C(C)C(Cl)=C3Cl)=O)CO)C=C1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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