Catalog No.
Product Name
Application
Product Information
Product Citation
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Dehydrogenase inhibitor
Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. -
Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.
- Xuechun Wang, .et al. , Int J Mol Sci, 2023, Mar 8;24(6):5204 PMID: 36982279
- R. San Gil, .et al. , bioRxiv, 2020, Jan
- Abdin AA, .et al. , Eur J Pharmacol., 2014, 742:102-12 PMID: 25218987
- Disulfiram blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase thus causing an unpleasant reaction when alcohol is consumed.
- Paul Mark Medina, .et al. , Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
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Dehydrogenase inhibitor
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs. Leflunomide is used to relieve symptoms caused by rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain. -
IMPDH inhibitor
Mycophenolate mofetil is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis (specifically guanine synthesis) which is necessary for the growth of T cells and B cells. - Ranolazine is a partial fatty acid oxidation inhibitor, shifts ATP production from fatty acid to more oxygen-efficient carbohydrate oxidation.
- Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP).
- Trilostane is an inhibitor of 3??-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.
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Dehydrogenase Inhibitor
CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities.- Naohisa Ichiki, .et al. , J Cancer, 2024, Feb 4;15(7):1779-1785 PMID: 38434963
- Takuji Sakuratani, .et al. , Virchows Arch, 2020, Aug 13 PMID: 32789692
- Egawa Y, .et al. , PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220
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GAPDH inhibitor
CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. -
DHODH inhibitor
Vidofludimus is a novel orally active and potent DHODH inhibitor. - ASP9521 is a novel, selective, orally bioavailable inhibitor of 17??-hydroxysteroid dehydrogenase type 5 (17bHSD5, AKR1C3).
- Belen Crespo, .et al. , Int J Mol Sci, 2024, Jan 25;25(3):1471 PMID: 38338747
- Monoammoniumglycyrrhizinate is a constituent of the licorice root that has vital anti-viral activities that have been shown to inhibit the expression of 11_?HSD2 (11_?hydroxysteroid dehydrogenase type 2) via an indirect mechanism.
- Jung-Ho Lee, .et al. , J Nat Prod, 2021, Sep 24;84(9):2612-2616 PMID: 34411479
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ALDH2 Activator
Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2).- Xia Wang, .et al. , Nat Commun, 2024, Mar 22;15(1):2594 PMID: 38519490
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Dehydrogenase Inhibitor
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. -
alcohol dehydrogenase inhibitor
Fomepizole is an alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisonings in adults. -
Pyruvate dehydrogenase kinase inhibitor
Sodium Dichloroacetate, also known as CPC-211; DCA; X-11S, is a Pyruvate dehydrogenase kinase inhibitor potentially for the treatment of myocardia ischemia, ischemic. Sodium dichloroacetate also exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3. Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia. -
VEGFA inhibitor
PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis. -
DHODH inhibitor
BAY-2402234 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. -
Dehydrogenases substrate
Nitro blue tetrazolium chloride (NBT) is a substrate for dehydrogenases; is used with the alkaline phosphatase substrate 5-Bromo-4-Chloro-3-Indolyl Phosphate (BCIP) in western blotting and immunohistological staining procedures. -
inosine monophosphate dehydrogenase inhibitor
Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. -
dihydropyrimidine dehydrogenase inhibitor
Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity. -
inosine monophosphate dehydrogenase inhibitor
Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. -
the succinate dehydrogenase (SQR) enzyme inhibitor
Fluxapyroxad, a broad-spectrum fungicide, is an inhibitor of the succinate dehydrogenase (SQR) enzyme. -
ALDH1A1 inhibitor
Propachlor is a specific ALDH1A1 inhibitor. It is sometimes used as an herbicide. -
irreversible inhibitor of succinate dehydrogenase
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM.
