BIBR 953 (Dabigatran, Pradaxa)

Catalog No.: A10138

Thrombin inhibitor

BIBR 953 (Dabigatran, Pradaxa)

BIBR 953 (Dabigatran, Pradaxa) Chemical Structure

CAS NO. 211914-51-1

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

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5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $450.00

Special Price $360.00

100 mg

Regular Price: $720.00

Special Price $576.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tanaka M, .et al. Protease-activated receptor-1 negatively regulates proliferation of neural stem/progenitor cells derived from the hippocampal dentate gyrus of the adult mouse, J Pharmacol Sci, 2016, Jul;131(3):162-71 PMID: 27426918

Biological Activity

BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

Targets
Thrombin (Cell-free assay)
9.3 nM
In vitro (25°C) DMSO <1 mg/mL
Water 29 mg/mL (61.5 mM)
Ethanol 0.01 mg/mL (0.02 mM)
In vivo 10% Trifluoroacetic acid water solution 31 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09 mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10138
Actions Inhibitor
CAS No. 211914-51-1
Formula C25H25N7O3
M. Wt 471.5
Purity >98%
Synonyms BIBR-953, BIBR953
SMILES CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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