Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Tanaka M, .et al. Protease-activated receptor-1 negatively regulates proliferation of neural stem/progenitor cells derived from the hippocampal dentate gyrus of the adult mouse, J Pharmacol Sci, 2016, Jul;131(3):162-71 PMID: 27426918
Biological Activity
BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.
Targets
| Thrombin (Cell-free assay) | ||||
| 9.3 nM |
| In vitro (25°C) | DMSO | <1 mg/mL | |
| Water | 29 mg/mL (61.5 mM) | ||
| Ethanol | 0.01 mg/mL (0.02 mM) | ||
| In vivo | 10% Trifluoroacetic acid water solution | 31 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.21 mL | 106.04 mL | 212.09 mL |
| 0.5 mM | 4.24 mL | 21.21 mL | 42.42 mL |
| 1 mM | 2.12 mL | 10.6 mL | 21.21 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10138 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 211914-51-1 |
| Formula | C25H25N7O3 |
| M. Wt | 471.5 |
| Purity | >98% |
| Synonyms | BIBR-953, BIBR953 |
| SMILES | CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy BIBR 953 (Dabigatran, Pradaxa) | BIBR 953 (Dabigatran, Pradaxa) Supplier | purchase | cost | manufacturer | order | distributor | buy 211914-51-1| 211914-51-1 Supplier | purchase 211914-51-1 | 211914-51-1 cost | 211914-51-1 manufacturer | order 211914-51-1 | 211914-51-1 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.