Bimatoprost isopropyl ester acts as a drug intermediate with a specific focus on the prostaglandin F2α analogs. It is characterized by a double bond at the 13-14 position and an inverted hydroxyl group at C-15. Notably, this compound has demonstrated significant biological activity, exhibiting an IC50 of 30 nM in FP receptor binding assays, indicating its potential role as an impurity in latanoprost formulations. Additionally, in vivo studies revealed that a dose of 3 μg can lead to a 1.9 mmHg decrease in intraocular pressure in normotensive cynomolgus monkeys, making it a valuable reagent for research involving ocular therapies.
Bimatoprost isopropyl ester acts as a drug intermediate with a specific focus on the prostaglandin F2α analogs. It is characterized by a double bond at the 13-14 position and an inverted hydroxyl group at C-15. Notably, this compound has demonstrated significant biological activity, exhibiting an IC50 of 30 nM in FP receptor binding assays, indicating its potential role as an impurity in latanoprost formulations. Additionally, in vivo studies revealed that a dose of 3 μg can lead to a 1.9 mmHg decrease in intraocular pressure in normotensive cynomolgus monkeys, making it a valuable reagent for research involving ocular therapies.
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