BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. It enhances the activity of wild-type Parkin by stimulating its autoubiquitination and promotes the monoubiquitination of Miro1, with an EC50 of 0.17 μM. BIO-2007817 is a valuable tool for studying Parkin-mediated mitophagy and neurodegenerative diseases such as Parkinson's disease.
BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. It enhances the activity of wild-type Parkin by stimulating its autoubiquitination and promotes the monoubiquitination of Miro1, with an EC50 of 0.17 μM. BIO-2007817 is a valuable tool for studying Parkin-mediated mitophagy and neurodegenerative diseases such as Parkinson's disease.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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