E3 ligase

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  1. APC/C inhibitor

    TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM.
  2. E3 ubiquitin ligase inhibitor

    Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.
  3. Ubiquitin E3 Ligase Inhibitor

    SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation.
  4. Hdm2 ubiquitin ligase Inhibitor

    HLI-98C, an analog, indeed inhibited Mdm2 E3 ligase activity.
  5. Skp2 Inhibitor

    SKPin C1 inhibits Skp2-mediated p27 degradation and it induces cell cycle arrest.
  6. HDM2 inhibitor

    HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription.
  7. E3 Ligase inhibitor

    Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.
  8. cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.
  9. cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER.
  10. UHRF1 inhibitor

    NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.
  11. Skp2 inhibitor

    SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation.
  12. E3 ligase activity inhibitor

    Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor.

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