Bis-PEG25-TFP ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features a TFP (trifluoroethyl phthalimide) moiety that facilitates the conjugation of target proteins to ubiquitin ligases, promoting their degradation via the cellular ubiquitin-proteasome system. Bis-PEG25-TFP ester is essential for the development of targeted protein degradation therapies and supports various applications in chemical biology and drug discovery research.
Bis-PEG25-TFP ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features a TFP (trifluoroethyl phthalimide) moiety that facilitates the conjugation of target proteins to ubiquitin ligases, promoting their degradation via the cellular ubiquitin-proteasome system. Bis-PEG25-TFP ester is essential for the development of targeted protein degradation therapies and supports various applications in chemical biology and drug discovery research.
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