BIX-01294 trihydrochloride is a reversible and selective inhibitor of G9a and GLP histone methyltransferases, with reported IC50 values of 1.7 μM and 0.9 μM, respectively. It functions by competing for binding at the N-terminal site of substrate lysine residues, thereby inhibiting methylation processes. BIX-01294 trihydrochloride has been shown to induce necroptosis and autophagy, demonstrating antitumor activity particularly in recurrent tumor cells. Its utilization in research may further elucidate the roles of histone methylation in cancer biology and potential therapeutic strategies.
BIX-01294 trihydrochloride is a reversible and selective inhibitor of G9a and GLP histone methyltransferases, with reported IC50 values of 1.7 μM and 0.9 μM, respectively. It functions by competing for binding at the N-terminal site of substrate lysine residues, thereby inhibiting methylation processes. BIX-01294 trihydrochloride has been shown to induce necroptosis and autophagy, demonstrating antitumor activity particularly in recurrent tumor cells. Its utilization in research may further elucidate the roles of histone methylation in cancer biology and potential therapeutic strategies.
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