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BIX 02189

BIX 02189

Name: BIX 02189
Brand: Adooq Bioscience
SKU: A10151
Rating: 100 (1 reviews)

Catalog No.: A10151

MEK inhibitor

Product Citations (1)

BIX 02189 Chemical Structure

CAS NO. 1094614-85-3

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
50 mg	$680.00
100 mg	$980.00
10mM * 1mL in DMSO	$138.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq BIX 02189

Mitsunori Miyazaki, .et al. TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738

Biological Activity

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

Targets

Target	Value
MEK5	IC50: 1.5nM
ERK5	IC50: 59nM
TGFβR1	IC50: 580nM
MEK1	IC50: >6.2μM
MEK2	IC50: >6.2μM
ERK1	IC50: >6.2μM
JNK2	IC50: >6.2μM
EGFR	IC50: >6.3μM
STK16	IC50: >6.3μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 56 mg/mL (127.11 mM)
	Water	Insoluble
	Ethanol	75 mg/mL (170.24 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.7 mL	113.51 mL	227.01 mL
0.5 mM	4.54 mL	22.7 mL	45.4 mL
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10151
Actions	Inhibitor
CAS No.	1094614-85-3
Formula	C27H28N4O2
M. Wt	440.5
Purity	>98%
Synonyms	BIX02189, BIX-02189
SMILES	CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.