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BIX 02189

Catalog No.: A10151

MEK inhibitor

BIX 02189

BIX 02189 Chemical Structure

CAS NO. 1094614-85-3

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$680.00
100 mg
$980.00
10mM * 1mL in DMSO
$138.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Mitsunori Miyazaki, .et al. TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738

Biological Activity

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
Targets
Target Value
MEK5IC50: 1.5nM
ERK5IC50: 59nM
TGFβR1IC50: 580nM
MEK1IC50: >6.2μM
MEK2IC50: >6.2μM
ERK1IC50: >6.2μM
JNK2IC50: >6.2μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM
In vitro (25°C) DMSO Warmed: 56 mg/mL (127.11 mM)
Water Insoluble
Ethanol 75 mg/mL (170.24 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.51 mL 227.01 mL
0.5 mM 4.54 mL 22.7 mL 45.4 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10151
Actions Inhibitor
CAS No. 1094614-85-3
Formula C27H28N4O2
M. Wt 440.5
Purity >98%
Synonyms BIX02189, BIX-02189
SMILES CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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