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BIX 02189

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MEK inhibitor

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Catalog No. A10151

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BIX 02189 5mg A10151-5

Regular Price: €85.50

Special Price: €76.95

BIX 02189 10mg A10151-10

Regular Price: €152.00

Special Price: €136.80

BIX 02189 50mg A10151-50

Regular Price: €646.00

Special Price: €581.40

BIX 02189 100mg A10151-100

Regular Price: €931.00

Special Price: €837.90

BIX 02189 10mM * 1mL in DMSO A10151-10mM-D

Regular Price: €131.10

Special Price: €117.99

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

BIX 02189

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Publications citing Adooq Products
BIX 02189  Citations (1)
  • Mitsunori Miyazaki, .et al. TSC2/Rheb signaling mediates ERK坼dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424每433 PMID: 28286738

Chemical Information

Catalog Num A10151
Actions Inhibitor
M. Wt 440.5
Formula C27H28N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1094614-85-3
Synonyms BIX02189, BIX-02189
SMILES code CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
Chemical Name 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

Biological Activity

Description
 BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
Targets
Target Value
MEK5IC50: 1.5nM
ERK5IC50: 59nM
TGFβR1IC50: 580nM
MEK1IC50: >6.2μM
MEK2IC50: >6.2μM
ERK1IC50: >6.2μM
JNK2IC50: >6.2μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM

Solubility

Solubility (25°C) * In vitro DMSO 60 mg/mL heating (136.19 mM)
Water <1 mg/mL (<1 mM)
Ethanol 80 mg/mL (181.59 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.51 mL 227.01mL
0.5 mM 4.54 mL 22.7 mL 45.4 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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