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$0.00 - Mitsunori Miyazaki, .et al. TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts, FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738
Biological Activity
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
Targets
| Target | Value |
|---|---|
| MEK5 | IC50: 1.5nM |
| ERK5 | IC50: 59nM |
| TGFβR1 | IC50: 580nM |
| MEK1 | IC50: >6.2μM |
| MEK2 | IC50: >6.2μM |
| ERK1 | IC50: >6.2μM |
| JNK2 | IC50: >6.2μM |
| EGFR | IC50: >6.3μM |
| STK16 | IC50: >6.3μM |
| In vitro (25°C) | DMSO | 60 mg/mL heating (136.19 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 80 mg/mL (181.59 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.7 mL | 113.51 mL | 227.01 mL |
| 0.5 mM | 4.54 mL | 22.7 mL | 45.4 mL |
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10151 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 440.5 |
| Formula | C27H28N4O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1094614-85-3 |
| Synonyms | BIX02189, BIX-02189 |
| SMILES | CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4 |
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