BM-531 is a dual-action thromboxane receptor (TXA2) inhibitor that also functions as a thromboxane synthase inhibitor. This compound demonstrates significant anti-aggregatory effects on human citrated platelet-rich plasma, effectively inhibiting arachidonic acid-induced aggregation with an ED100 of 0.125 μM and U-46619-induced aggregation with an ED50 of 0.482 μM. Additionally, BM-531 is shown to inhibit contraction in porcine uterine smooth muscle induced by high potassium levels, making it a valuable tool for research in thrombosis and uterine contractility studies.
BM-531 is a dual-action thromboxane receptor (TXA2) inhibitor that also functions as a thromboxane synthase inhibitor. This compound demonstrates significant anti-aggregatory effects on human citrated platelet-rich plasma, effectively inhibiting arachidonic acid-induced aggregation with an ED100 of 0.125 μM and U-46619-induced aggregation with an ED50 of 0.482 μM. Additionally, BM-531 is shown to inhibit contraction in porcine uterine smooth muscle induced by high potassium levels, making it a valuable tool for research in thrombosis and uterine contractility studies.
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