Fig. 1 · Structure
Documents & Downloads
BM-573
TXA₂ Modulator
BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator that functions through specific inhibition of thromboxane synthase (TxAS) and antagonism of thromboxane receptors (TP). With an IC50 of 1.3 nM, it effectively inhibits platelet aggregation induced by arachidonic acid or TXA₂ analogues without affecting cyclooxygenase enzymes (COX-1/COX-2), thus preserving other prostaglandin syntheses. BM-573 also demonstrates a significant inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle. This compound is valuable for research applications in atherosclerosis, myocardial infarction, pulmonary hypertension, and shock.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 284464-83-1 |
| Applications | TXA₂ Modulator |
| Formula | C18H22N4O5S |
| Molecular Weight | 406.46 |
| SMILES | CC(C)(C)NC(NS(C1=C(NC2=CC=C(C)C=C2)C=CC([N+]([O-])=O)=C1)(=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.