BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator that functions through specific inhibition of thromboxane synthase (TxAS) and antagonism of thromboxane receptors (TP). With an IC50 of 1.3 nM, it effectively inhibits platelet aggregation induced by arachidonic acid or TXA₂ analogues without affecting cyclooxygenase enzymes (COX-1/COX-2), thus preserving other prostaglandin syntheses. BM-573 also demonstrates a significant inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle. This compound is valuable for research applications in atherosclerosis, myocardial infarction, pulmonary hypertension, and shock.
BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator that functions through specific inhibition of thromboxane synthase (TxAS) and antagonism of thromboxane receptors (TP). With an IC50 of 1.3 nM, it effectively inhibits platelet aggregation induced by arachidonic acid or TXA₂ analogues without affecting cyclooxygenase enzymes (COX-1/COX-2), thus preserving other prostaglandin syntheses. BM-573 also demonstrates a significant inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle. This compound is valuable for research applications in atherosclerosis, myocardial infarction, pulmonary hypertension, and shock.
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