BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), demonstrating IC50 values of 0.8 nM and 0.3 nM for the CK2α and CK2α′ isoforms, respectively. By mimicking ATP, BMS-135 effectively binds to the active site of CK2, inhibiting its serine/threonine phosphorylation activity. This inhibition results in the suppression of cellular proliferation and exhibits anti-tumor properties. BMS-135 is particularly relevant for research applications in colon cancer studies.
BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), demonstrating IC50 values of 0.8 nM and 0.3 nM for the CK2α and CK2α′ isoforms, respectively. By mimicking ATP, BMS-135 effectively binds to the active site of CK2, inhibiting its serine/threonine phosphorylation activity. This inhibition results in the suppression of cellular proliferation and exhibits anti-tumor properties. BMS-135 is particularly relevant for research applications in colon cancer studies.
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