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BMS 180742

Catalog No.: A77935
Thrombin Inhibitor
BMS 180742 is a selective thrombin exosite inhibitor that disrupts thrombin's ability to interact with its substrates. It exhibits significant inhibition of thrombin-mediated processes, making it a valuable tool for investigating coagulation pathways. This compound is particularly useful in research applications focusing on the modulation of hemostasis and thrombin-related disorders. Notably, BMS 180742 does not exhibit inhibition of arterial thrombosis, providing insights into selective targeting in thrombosis research.
BMS 180742 138828-04-3 Thrombin Inhibitor
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Size Price Stock Qty
25mg
$1,275.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBMS 180742 is a selective thrombin exosite inhibitor that disrupts thrombin's ability to interact with its substrates. It exhibits significant inhibition of thrombin-mediated processes, making it a valuable tool for investigating coagulation pathways. This compound is particularly useful in research applications focusing on the modulation of hemostasis and thrombin-related disorders. Notably, BMS 180742 does not exhibit inhibition of arterial thrombosis, providing insights into selective targeting in thrombosis research.
Product Information
Catalog NumA77935
FormulaC67H93N11O22
Molecular Weight1404.52
CAS Number138828-04-3
Sequence{Suc}-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr-{(Cyclohexyl)Ala}-Gln
Sequence shortening{Suc}-FEPIPEEY-{(Cyclohexyl)Ala}-Q
SMILESC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CCC(O)=O)=O)=O)CCC(O)=O)=O)CCC1)[C@H](CC)C)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5CCCCC5)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC3
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Proteases > Thrombin