BMS-223131 is a potent maxi-K potassium channel opener, primarily targeting potassium channels to enhance K+ efflux and hyperpolarize cell membranes, leading to reduced Ca2+ influx. It demonstrates strong inhibitory activity on the CYP2C9 enzyme (IC50 = 1.7 μM) and modulates several other CYP enzymes, including CYP1A2, CYP2C19, CYP2D6, and CYP3A4. This compound is valuable in research focused on neurological diseases, particularly stroke, due to its ability to influence ion channel activity and cellular excitability.
BMS-223131 is a potent maxi-K potassium channel opener, primarily targeting potassium channels to enhance K+ efflux and hyperpolarize cell membranes, leading to reduced Ca2+ influx. It demonstrates strong inhibitory activity on the CYP2C9 enzyme (IC50 = 1.7 μM) and modulates several other CYP enzymes, including CYP1A2, CYP2C19, CYP2D6, and CYP3A4. This compound is valuable in research focused on neurological diseases, particularly stroke, due to its ability to influence ion channel activity and cellular excitability.
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