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BMS 599626 (AC480)

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EGFR Inhibitor

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Catalog No. A11209

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BMS 599626 5mg A11209-5

Regular Price: €76.00

Special Price: €68.40

BMS 599626 10mg A11209-10

Regular Price: €133.00

Special Price: €119.70

BMS 599626 50mg A11209-50

Regular Price: €380.00

Special Price: €342.00

BMS 599626 100mg A11209-100

Regular Price: €665.00

Special Price: €598.50

BMS 599626 (AC480) 10mM * 1mL in DMSO A11209-10mM-D

Regular Price: €142.50

Special Price: €128.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.

BMS 599626 (AC480)

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Chemical Information

Catalog Num A11209
Actions Inhibitor
M. Wt 567.1
Formula C27H27FN8O3.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873837-23-1
Synonyms BMS-599626, BMS599626, AC-480
SMILES CC1=C2C(=NC=NN2C=C1NC(=O)OC[[email protected]@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl

Biological Activity

Description
 BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.

Solubility

Solubility (25°C) * In vitro DMSO 113 mg/mL (199.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol 20 mg/mL (35.27 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.63 mL 88.17 mL 176.34mL
0.5 mM 3.53 mL 17.63 mL 35.27 mL
1 mM 1.76 mL 8.82 mL 17.63 mL
5 mM 0.35 mL 1.76 mL 3.53 mL

*The above data is based on the productmolecular weight 567.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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