BMS 599626 (AC480)

Catalog No.: A11209

EGFR Inhibitor

BMS 599626 (AC480)

BMS 599626 (AC480) Chemical Structure

CAS NO. 873837-23-1

BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.

Availability: In stock

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5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $400.00

Special Price $320.00

100 mg

Regular Price: $700.00

Special Price $560.00

10mM * 1mL in DMSO

Regular Price: $150.00

Special Price $120.00

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Biological Activity

BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.
In vitro (25°C) DMSO 104 mg/mL (196.02 mM)
Water Insoluble
Ethanol 18 mg/mL (33.92 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.63 mL 88.17 mL 176.34 mL
0.5 mM 3.53 mL 17.63 mL 35.27 mL
1 mM 1.76 mL 8.82 mL 17.63 mL
5 mM 0.35 mL 1.76 mL 3.53 mL

*The above data is based on the productmolecular weight 567.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11209
Actions Inhibitor
CAS No. 873837-23-1
Formula C27H27FN8O3.HCl
M. Wt 567.1
Purity >98%
Synonyms BMS-599626, BMS599626, AC-480
SMILES CC1=C2C(=NC=NN2C=C1NC(=O)OC[[email protected]@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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