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BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.
| In vitro (25°C) | DMSO | 104 mg/mL (196.02 mM) | |
| Water | Insoluble | ||
| Ethanol | 18 mg/mL (33.92 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.63 mL | 88.17 mL | 176.34 mL |
| 0.5 mM | 3.53 mL | 17.63 mL | 35.27 mL |
| 1 mM | 1.76 mL | 8.82 mL | 17.63 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.53 mL |
*The above data is based on the productmolecular weight 567.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11209 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 873837-23-1 |
| Formula | C27H27FN8O3.HCl |
| M. Wt | 567.1 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | BMS-599626, BMS599626, AC-480 |
| SMILES | CC1=C2C(=NC=NN2C=C1NC(=O)OC[[email protected]@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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