Biological Activity
BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity.
In vitro (25°C) | DMSO | 104 mg/mL (196.02 mM) | |
Water | Insoluble | ||
Ethanol | 18 mg/mL (33.92 mM) | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.63 mL | 88.17 mL | 176.34 mL |
0.5 mM | 3.53 mL | 17.63 mL | 35.27 mL |
1 mM | 1.76 mL | 8.82 mL | 17.63 mL |
5 mM | 0.35 mL | 1.76 mL | 3.53 mL |
*The above data is based on the productmolecular weight 567.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11209 |
---|---|
Actions | Inhibitor |
CAS No. | 873837-23-1 |
Formula | C27H27FN8O3.HCl |
M. Wt | 567.1 |
Purity | >98% |
Synonyms | BMS-599626, BMS599626, AC-480 |
SMILES | CC1=C2C(=NC=NN2C=C1NC(=O)OC[[email protected]@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
ASP8273 (Naquotinib)
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with po…
AG-1478 (Tyrphostin AG-1478)
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
SU-5402
SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor…
AEE788
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, …
WHI-P180
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
Gefitinib (Iressa)
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
Keywords:buy BMS 599626 (AC480) | BMS 599626 (AC480) Supplier | purchase | cost | manufacturer | order | distributor | buy 873837-23-1| 873837-23-1 Supplier | purchase 873837-23-1 | 873837-23-1 cost | 873837-23-1 manufacturer | order 873837-23-1 | 873837-23-1 distributor